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来源:安拓思纳米技术(苏州)有限公司发布时间:2016-12-27 16:25:01 浏览次数:

Thank you for your interest in our products, We are delighted to introduce you to our new product -ZE-16

Hot-Melt Extrusion technique

Hot-Melt Extrusion technique or named Melt Extrusion technique,It's a new preparation technology that the Europe, North America and Japan vigorously developed in recent years. The main function is to improve the solubility of the drug, the preparation of sustained release formulations……

ZE-16

 

Basic parameters:

 

Capacity :3kg/h

Screw diameter (mm) :15.6

Screw groove depth (mm) :3.3

Maximum drive power(Kw) :1.5

Maximum speed(rpm) :600

Maximum output torque(N/m) :33

Molding caliber(mm) :2

Minimum sample weight(g) :30

Residues(ml) :20

 

Technical advantages

l Continuous production

l Excellent reproducibility

l No dust pollution

l Online control

 

Applications

1. Adalat SL → Nifedipine    

 Accessories reinforcing material:PEG

2. Cris-PEG → Griseofulvin  

 Accessories reinforcing material:PEG

3. Kaletra   → Lopinavir / ritonavir

 Accessories reinforcing material:Copovidone

4. Rezulin   → Troglitazone

 Accessories reinforcing material:Povidone

 

Extrusion principle 

l HME technology : Two or more of the samples were placed in a temperature controlled barrel,together heated to a molten state.Under the action of the screw, the samples were cut, mix, and finally through a die under a certain pressure,become dispersed uniformly shaped product

l HME basic idea:Place multiple segments threaded element within different functions in the axial space.So that multiple samples size decreases, and mutual penetration and exchange,eventually achieve molecular level mixing。

 

Threaded element with different functions

 

Process analysis technology 

 

Evaluation of the right screw configuration 

 

Analysis:

Screw configuration 1 with better dispersion and homogenization

Different speeds obtained a different result

 

Effect of speed on the dispersion and homogenizing effect

 

Analysis:

Better homogeneity and dispersion with lower screw speed.

When the speed is too fast, the sample residence time is too short.The sample can not be sufficiently melted, dispersed poorly.

Summary of melt parameters:

Right screw combination

The correct speed and outlet diameter

Suitable temperature setting

 

Core Component Description:

 

l Screw section:Screw element, mandrel, conveying elements and mixing elements are made Ralloy WR30

l Siemens control systems, data export USB

l Gasket material: Sanitary Teflon and silicone。

l Motor: 1.5Kw

l Bearing: SKF and INA

l Electronically controlled switch:Germany KOELER,Overload protection


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